Gresini will be an independent team from 2022 and on and will drop Aprilia after 2021. Looks like the end of Aprilia in GP unless another entity/owner picks the project up but with how bad they’ve been doing, I find that doubtful.

https://www.motogp.com/en/news/2020/12/14/gresini-racing-from-2022-the-motogp-project-is-reality/359968