Originally Posted by
TFOGGuys
Tire pressures will rise with altitude (as ambient pressure becomes less). I would advise setting pressure before you leave, then recheck your cold tire pressures every morning as you lose altitude (you'll probably see about a 2 psi loss between here and Vegas).
38 Front and 40 Rear should work well as long as you're not super heavily loaded, but for extended high speed (85+, more than an hour at a time) or very high ambient temps, I'd push it to 40 psi front and 42 rear to reduce running temps and extend wear. Tire pressures should always be checked cold, as a warm tire may see a pressure increase of as much as 20%.